Description
Clinical Applications of Endogenous Biomarkers using PBPK
Tutors: Matt Harwood, Aneesh Karkhanis, Jakub Witkowski, Xian Pan
Date: November 16-20, 2026 | ONLINE
Time: 15:00-18:00 Daily (UK time)
Number of participants: Minimum 6 / Maximum 40
Course Title: A Hands-On Workshop to explore the clinical applications of Endogenous Biomarkers using PBPK
This workshop is ideal for those interested in developing PBPK models for endogenous biomarkers as sensitive and specific markers of ADME-related enzymes and transporters. Attendees will examine how these models assess metabolic and transporter-mediated DDI risk and how biomarkers can refine PBPK models for disease-state applications. Practical exercises will reinforce concepts and demonstrate the use of Simcyp features to develop effective endogenous biomarker models.
Objectives
Key aspects covered in this course:
- Development of biomarker PBPK models, including key assumptions, verification, and real-world applications.
- Leverage established Simcyp features for ‘small molecule’ files to develop effective biomarker models.
- Hands-on experience building biomarker models using the dedicated ‘Endogenous’ module within the Simcyp Simulator.
- Explore the use of PBPK biomarker models as sensitive and selective markers for ADME-related metabolic enzymes.
- Understand how endogenous PBPK models are applied in clinical and regulatory contexts, including their role in assessing DDI risk.
- Examine biomarkers for hepatic and renal transporters and their contribution to evaluating transporter-mediated DDI risk.
- Employing biomarker model assessments to refine PBPK model system parameters in disease.
Certificate
By completing/passing this course, you will attain the certificate Biomarkers Certificate Online
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