Description
This workshop introduces the ocular modelling feature first introduced in Version 23 of the Simcyp Simulator. No advanced Simcyp experience is required, though some prior knowledge of PBPK modelling is helpful.
The course provides a structured overview of the ocular model, including the pathways compounds are expected to follow based on their physicochemical properties. Common dosing strategies — topical application and intravitreal injection — are covered in detail, along with the application of controlled release profiles for both routes. Given the large number of parameters the model requires, dedicated time is spent discussing experimental data availability, Simcyp-based predictions, and practical approaches for handling parameters that remain unknown. Hands-on examples are included throughout to build confidence and familiarity with the module.
Course Structure
The course is accessible for 30 days from the date of registration. It provides approximately 2.5 hours of video instruction plus around 1 hour of hands-on Simcyp Simulator work, with a total expected commitment of 3.5+ hours. On successful completion, you will receive a certificate of achievement.
A 2-day Simcyp Simulator licence is included with your registration, providing sufficient access to complete all practical exercises. One office hour with a senior Simcyp scientist is also included and can be scheduled after registration to support your learning and address specific questions.
Lectures and slides remain accessible within the portal for the full 30-day period. Recordings and materials are not available for download, though you are welcome to take your own notes.
Each purchase covers a single seat — login credentials must not be shared. Additional seats must be purchased separately for each individual. Once registered, log into your Dashboard to begin immediately.
Session Outline
|
Duration |
Topic |
|---|---|
|
10 min |
Background and motivation for ocular modelling in Simcyp |
|
20 min |
Model tour and overview |
|
45 min |
Basic dosing strategies: topical and intravitreal routes |
|
30 min |
Controlled release profiles for dosing |
|
30 min |
Model parameters: experimental data, Simcyp predictions, and managing unknowns |
|
1 hour |
Hands-on examples: topical and intravitreal dosing, distribution and clearance |
Your Instructors
This workshop is led by world-class scientists from Certara's Simcyp division, each bringing deep expertise in non-oral drug delivery and mechanistic modeling
Objectives
Key Aspects Covered in This Course
- Understand the principles of PBPK modelling as applied within the Simcyp Simulator.
- Navigate the Simcyp ocular representation of the eye as both a dosing route and pharmacological target.
- Simulate topical ocular drug application and intravitreal injection dosing strategies.
- Apply controlled release profiles to ocular dosing scenarios.
- Identify and manage the parameter requirements of the ocular model, including experimentally derived values, Simcyp predictions, and strategies for handling unknown parameters.
- Gain hands-on experience with the ocular module through guided practical examples.
Certificate
By completing/passing this course, you will attain the certificate 007-OD Ocular
User Accounts and Registrations
The email address used for your user login must be an individual account. No sharing of user accounts between multiple individuals is allowed. Each user account (and any associated course registrations) is for a specific person, and cannot be transferred to a different individual once the course has started.
Course Materials
As a course registrant, you may view and read all materials related to your registered courses. However, you may not share, communicate, publish, copy or in any manner distribute to other parties the course materials, reference material provided, assignment solutions, quiz questions, exam questions, links or any other materials.
Cancellation Policy
Live Online Courses
There are no refunds for Live Online courses for cancellation or non-attendance by the participant. Certara retains the right to cancel the course 30 calendar days before the first session, in which case participants will receive a full refund.
e-Learning and Certifications
There are no refunds for e-Learning courses or certifications. Course expiration dates can be found on your Dashboard.
Electronic Communication
We will send you email notifications regarding your training courses, including enrollment confirmations, purchase confirmations, and reminders of upcoming sessions. We will also send email for general announcements about the site. You can opt out of these emails if you wish (located in your profile).
Details
Full terms and conditions applicable to this LMS are available at the Certara Legal web page.
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