051 Simcyp Focused Workshop: Non-oral absorption - April 4-8, 2022

Content
13 modules

Rating

Instructor
Kelly Turton

Released
03 Nov 2021

Price
£1,100.00

Description

Broadening the range and utilization of in silico-based mechanistic prediction and analysis of drug absorption after non-oral application. Mechanistic modeling of the topical drug application, development of mechanistic physiologically-based in vitro-in vivo correlations (IVIVCs), and virtual bioequivalence (VBE) concepts.

Live Online Courses

There are no refunds for Live Online courses.  Certara retains the right to cancel the course 30 calendar days before the first session, in which case participants will receive a full refund.

Objectives

Key aspects covered in this course:

  • Recognize the opportunities and challenges in applying quantitative modelling and simulation tools in the field of non-oral drug formulation development.
  • The use of Multi-Phase Multi-Layer (MPML) MechDermA model for simulating the absorption of drug from the skin
  • Development a physiologically based pharmacokinetic framework for modelling in vitro and in vivo skin permeation of topical/transdermal products – establishing dermal in vitro in vivo extrapolation
  • Utilization of IVPT module for the in vitro skin permeation simulation and further extrapolation to in vivo situation (IVIVE)
  • Different types of topically formulations – solutions, emulsions (O/W, W/O), emulsions with solid particles, suspensions, patches
  • Understanding and modeling the metamorphosis of the topical formulations when applied on the skin surface
  • The use of MechVAM and MechRAM models for simulating the absorption of drug after vaginal and rectal application, specifically.
  • Development of mechanistic physiologically-based in vitro-in vivo correlations (IVIVCs) for dermally applied with discussion around case studies
  • Virtual bioequivalence for dermally applied with discussion around case studies

Certificate

By completing/passing this course, you will attain the certificate Non-oral Absorption

1.
Pre Course Questionnaire - Your experience, expectations and area of interest, an optional survey to take prior to the course.
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2.
Agenda, Non-oral absorption - 4-8 April 2022
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3.
Pre Workshop Reading List, A selection of publications related to the Simcyp Simulator and model-informed drug development.
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4.
Simcyp Simulator Download instructions (Amazon Workspaces download)
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5.
A beginners Introduction to the Simcyp Simulator
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6.
Slide Decks and Files for Loading
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7.
Hands-on Materials
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8.
Presentation Recordings - Non-oral absorption
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9.

Non-oral absorption: Session 1 WebEx (UK Time Zone)

10.

Non-oral absorption: Session 2 WebEx (UK Time Zone)

11.

Non-oral absorption: Session 3 WebEx (UK Time Zone)

12.

Non-oral absorption: Session 4 WebEx (UK Time Zone)

13.
Survey, please complete for Certificate of completion
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