Model-informed Drug Development Intensive Interactive Courses

Certara UK Limited is running a Simcyp hands-on workshop discussing the changes to pharmacokinetics during pregnancy and the prediction of pharmacokinetics (including in the milk) during lactation. Population based Physiologically Based Pharmacokinetic (PBPK) approach will be utilized to describe the pharmacokinetics during pregnancy and lactation and to determine population variability. The major topics covered are: Maternal and fetal gestational age-dependent physiological changes Prediction of maternal and fetal drug pharmacokinetics Ways of incorporating ex vivo experimental data on transplacental kinetics within the PBPK model Handling gestational age-varying covariates during simulation Prediction of PK in breastfeeding mothers and milk exposure using lactation models Prediction of infant dose for breastfed infant This course will be run using the Amazon Workspaces in Cloud; please ensure you have access to a computer. Read More