048 Simcyp Focused Workshop: DDI Predicting and evaluating complex DDIs - March 14-18, 2022

Content
14 modules

Instructor
Kelly Turton

Released
03 Nov 2021

Price
£1,100.00

Description

Predicting and evaluating complex DDIs—application of the Simcyp Population-based Simulator to real-life cases.

Live Online Courses

There are no refunds for Live Online courses.  Certara retains the right to cancel the course 30 calendar days before the first session, in which case participants will receive a full refund.

Objectives

Participants will learn good practices in combining data from both in vitro and clinical studies, whilst
gaining experience in using such data within physiologically-based dynamic models to evaluate the
DDI liability of drug candidates.
• Static vs. dynamic models (including discussion around regulatory guidance)
• Metabolic and transporter mediated DDIs
• Competitive inhibition, mechanism-based inhibition, induction, and suppression
• Complex DDIs involving combined interaction mechanisms and multiple inhibitors (including
inhibitory metabolites)
• Importance of in vitro study design
• The role of non-hepatic metabolism in DDIs
• Use of parameter estimation and sensitivity analysis
• Optimal clinical study design
• Special populations—identification of individuals at risk of DDI

Certificate

By completing/passing this course, you will attain the certificate Certificate of Completion - DDI

1.
Pre Course Questionnaire - Your experience, expectations and area of interest, an optional survey to take prior to the course.
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2.
DDI Agenda, March 14-18, 2022
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3.
Pre Workshop Reading List, A selection of publications related to the Simcyp Simulator and model-informed drug development.
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4.
Simcyp Simulator Download instructions (Amazon Workspaces download)
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5.
A beginners Introduction to the Simcyp Simulator
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6.
Slide Decks and Files for Loading - DDI
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7.
Hands-on Materials
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8.
Presentation Recordings - DDI
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9.

DDI: Session 1 Webex (UK Time Zone)

10.

DDI: Session 2 Webex (UK Time Zone)

11.

DDI: Session 3 Webex (UK Time Zone)

12.

DDI: Session 4 Webex (UK Time Zone)

13.

DDI: Session 5 Webex (UK Time Zone)

14.
Survey, please complete for Certificate of completion
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