045 Simcyp Focused Workshop: Parameter estimation (PE) and pharmacodynamics (PD) - March 7-11, 2022

Content
14 modules

Instructor
Kelly Turton

Released
03 Nov 2021

Price
£1,100.00

Description

Parameter Estimation and Pharmacodynamics (PE/PD)
A systems pharmacology approach to modeling and simulation—accelerating model building and covariate recognition in drug development by combining top-down and bottom-up PBPK modeling of pharmacokinetics linked to drug response.
The workshop covers the concepts and the practical applications of integrating in vitro data and physiological knowledge with clinical
observations for the purpose of estimating unknown/uncertain model parameters. Delegates will work through different parameter
estimation examples using fitting tools and explore various PD models.

Live Online Courses

There are no refunds for Live Online courses.  Certara retains the right to cancel the course 30 calendar days before the first session, in which case participants will receive a full refund.

Objectives

Key aspects covered in this course:
• The theoretical basis for combining bottom-up and top-down modeling and simulation
• Parameter estimation:
– Step-by-step guidance on data entry, fitting, and interpretation of results
– Simultaneous fitting of PK and PD parameters
– Covariate recognition
– Exploring use of external optimization packages (eg, R) with embedded Simcyp engine in PE
• Pharmacodynamics:
– Understanding of various PD models available within the Simcyp Simulator
– Use of preliminary clinical data to model and simulate various covariate effects
(eg, genotypic/phenotypic differences, effects of diseases such as renal impairment or cirrhosis)
– PD at the relevant effect site (eg, liver)
– Custom scripting of user-defined PD models

Certificate

By completing/passing this course, you will attain the certificate Certificate of Completion - PEPD

1.
Pre Course Questionnaire - Your experience, expectations and area of interest, an optional survey to take prior to the course.
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2.
PEPD Agenda, March 7-11, 2022
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3.
Pre Workshop Reading List, A selection of publications related to the Simcyp Simulator and model-informed drug development.
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4.
Simcyp Simulator Download instructions (Amazon Workspaces download)
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5.
A beginners Introduction to the Simcyp Simulator
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6.
Slide Decks and Files for Loading - PEPD
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7.
Hands-on Materials
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8.
Presentation and Office Hour Recordings - PEPD
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9.

PEPD: Session 1 WebEx (UK Time Zone)

10.

PEPD: Session 2 WebEx (UK Time Zone)

11.

PEPD: Session 3 WebEx (UK Time Zone)

12.

PEPD: Session 4 WebEx (UK Time Zone)

13.

PEPD: QA and Conclusion WebEx (UK Time Zone)

14.
Survey, please complete for Certificate of completion
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