Description
June 2-6, 2025 | ONLINE
Mechanistic oral absorption modelling and prediction of bioavailability for drug products incorporating inter-subject variability. Theory and applications of the Simcyp Advanced Dissolution, Absorption, and Metabolism (ADAM) Model.
Gut wall permeability and first-pass metabolism
Drug solubility, dissolution, precipitation and supersaturation
Oral drug absorption incorporating food effects
Bioavailability and the impact of physiology and dosage form including salts
Entero-hepatic recirculation
Inter-individual variability assessment
Application of the SIVA Toolkit to the modeling of in vitro experiments to confirm and/or estimate parameters for PBPK simulations with a case study; mechanistic modeling of dissolution and precipitation in USP 2, USP 4, serial dilution, transfer and biphasic systems.
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Certificate
By completing/passing this course, you will attain the certificate Certificate of Completion - Absorption I
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