Description
March 17-21, 2025 | ONLINE
The aim of this workshop is to provide an overview of PBPK models to predict the pharmacokinetics of complex large molecules such as antibody-drug conjugates (ADCs), bispecific antibodies, and oligonucleotides. Of special interest will be the prediction of therapeutic protein concentration in the tumour and the application of a tumour model. Furthermore, the simulation of large molecules in the monkey and paediatrics will be discussed. Several model applications will also be presented.
The course runs live online sesions via Teams for approximatley 3 hours per day with optinal hands on learning outside of the sessions.
Live Online Courses
There are no refunds for Live Online courses. Certara retains the right to cancel the course 30 calendar days before the first session, in which case participants will receive a full refund.
Objectives
Key aspects covered in this course:
- Use of minimal and full physiologically-based pharmacokinetic (PBPK) models for antibody-drug conjugates (ADC) and their link to the small molecule Simulator
- Utilisation of the tumour model for large molecules to predict the drug concentration at the tumour site
- Introducing the concept of bispecific antibodies and the use of target-mediated drug disposition (TMDD) models for bispecific antibodies
- Introduction to modelling oligonucleotides
- Modelling and simulation of therapeutic proteins in the monkey and translation to humans
- Large molecules disposition in children
- Application of the large molecule models at different stages of drug development
Certificate
By completing/passing this course, you will attain the certificate Biologics II
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Course Materials
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Cancellation Policy
Live Online Courses
There are no refunds for Live Online courses for cancellation or non-attendance by the participant. Certara retains the right to cancel the course 30 calendar days before the first session, in which case participants will receive a full refund.
e-Learning and Certifications
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Details
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