Description
PBPK in specific populations
This workshop will provide an in-depth overview of generating populations for mechanistic PBPK, focusing on key
covariates to inform prediction of PK in healthy as well as ethnic and disease populations.
Objectives
Key aspects covered in this course:
- Population Building & Sampling: Master creating custom populations with Correlated Monte Carlo methods for realistic variability.
- Trial Design Optimisation: Match demographics to clinical trials and optimise study designs for accurate PK predictions.
- Ethnic Bridging: Focus on Japanese/Chinese/ North American populations for dose adjustments and inter-ethnic PK assessments.
- Organ Impairment: Model renal impairment and cirrhosis effects on PK parameters and dosing.
- Oncology Population: Simulate altered physiology in cancer patients for therapy optimisation.
- Obesity & Comorbidities: Scale PBPK models for obese subjects and associated conditions.
- Inflammatory Effects: Quantify cytokine-mediated downregulation of enzymes (e.g., Rheumatoid Arthritis impact on CYP3A4).
- Hands-On Simcyp Practice: Execute assignments with dedicated office hours for debugging
Certificate
By completing/passing this course, you will attain the certificate Certificate of Completion - Special Populations
User Accounts and Registrations
The email address used for your user login must be an individual account. No sharing of user accounts between multiple individuals is allowed. Each user account (and any associated course registrations) is for a specific person, and cannot be transferred to a different individual once the course has started.
Course Materials
As a course registrant, you may view and read all materials related to your registered courses. However, you may not share, communicate, publish, copy or in any manner distribute to other parties the course materials, reference material provided, assignment solutions, quiz questions, exam questions, links or any other materials.
Cancellation Policy
Live Online Courses
There are no refunds for Live Online courses for cancellation or non-attendance by the participant. Certara retains the right to cancel the course 30 calendar days before the first session, in which case participants will receive a full refund.
e-Learning and Certifications
There are no refunds for e-Learning courses or certifications. Course expiration dates can be found on your Dashboard.
Electronic Communication
We will send you email notifications regarding your training courses, including enrollment confirmations, purchase confirmations, and reminders of upcoming sessions. We will also send email for general announcements about the site. You can opt out of these emails if you wish (located in your profile).
Details
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