Description
June 2-6, 2025 | ONLINE
Parameter Estimation and Pharmacodynamics (PE/PD)
A systems pharmacology approach to modeling and simulation—accelerating model building and covariate recognition in drug development by combining top-down and bottom-up PBPK modeling of pharmacokinetics linked to drug response.
The workshop covers the concepts and the practical applications of integrating in vitro data and physiological knowledge with clinical
observations for the purpose of estimating unknown/uncertain model parameters. Delegates will work through different parameter
estimation examples using fitting tools and explore various PD models.
Live Online Courses
There are no refunds for Live Online courses. Certara retains the right to cancel the course 30 calendar days before the first session, in which case participants will receive a full refund.
Objectives
Key aspects covered in this course:
• The theoretical basis for combining bottom-up and top-down modeling and simulation
• Parameter estimation:
– Step-by-step guidance on data entry, fitting, and interpretation of results
– Simultaneous fitting of PK and PD parameters
– Covariate recognition
– Exploring use of external optimization packages (eg, R) with embedded Simcyp engine in PE
• Pharmacodynamics:
– Understanding of various PD models available within the Simcyp Simulator
– Use of preliminary clinical data to model and simulate various covariate effects
(eg, genotypic/phenotypic differences, effects of diseases such as renal impairment or cirrhosis)
– PD at the relevant effect site (eg, liver)
– Custom scripting of user-defined PD models
Certificate
By completing/passing this course, you will attain the certificate PEPD 2025
User Accounts and Registrations
The email address used for your user login must be an individual account. No sharing of user accounts between multiple individuals is allowed. Each user account (and any associated course registrations) is for a specific person, and cannot be transferred to a different individual once the course has started.
Course Materials
As a course registrant, you may view and read all materials related to your registered courses. However, you may not share, communicate, publish, copy or in any manner distribute to other parties the course materials, reference material provided, assignment solutions, quiz questions, exam questions, links or any other materials.
Cancellation Policy
Live Online Courses
There are no refunds for Live Online courses for cancellation or non-attendance by the participant. Certara retains the right to cancel the course 30 calendar days before the first session, in which case participants will receive a full refund.
e-Learning and Certifications
There are no refunds for e-Learning courses or certifications. Course expiration dates can be found on your Dashboard.
Electronic Communication
We will send you email notifications regarding your training courses, including enrollment confirmations, purchase confirmations, and reminders of upcoming sessions. We will also send email for general announcements about the site. You can opt out of these emails if you wish (located in your profile).
Details
Full terms and conditions applicable to this LMS are available at the Certara Legal web page.
Certara is committed to protecting your privacy. Details of our privacy policy are available at the Privacy web page.
Shopping Cart
Your cart is empty