Content
8 modules
Instructor
Kelly Turton
Released
09 Feb 2024
Price
£1,300.00
Description
Broadening the range and utilization of in silico-based mechanistic prediction and analysis of drug absorption after non-oral application. Mechanistic modeling of the topical drug application, development of mechanistic physiologically-based in vitro-in vivo correlations (IVIVCs), and virtual bioequivalence (VBE) concepts.
Live Online Courses
There are no refunds for Live Online courses. Certara retains the right to cancel the course 30 calendar days before the first session, in which case participants will receive a full refund.
Objectives
Key aspects covered in this course:
- Recognize the opportunities and challenges in applying quantitative modelling and simulation tools in the field of non-oral drug formulation development.
- The use of Multi-Phase Multi-Layer (MPML) MechDermA model for simulating the absorption of drug from the skin
- Development a physiologically based pharmacokinetic framework for modelling in vitro and in vivo skin permeation of topical/transdermal products – establishing dermal in vitro in vivo extrapolation
- Utilization of IVPT module for the in vitro skin permeation simulation and further extrapolation to in vivo situation (IVIVE)
- Different types of topically formulations – solutions, emulsions (O/W, W/O), emulsions with solid particles, suspensions, patches
- Understanding and modeling the metamorphosis of the topical formulations when applied on the skin surface
- The use of MechVAM and MechRAM models for simulating the absorption of drug after vaginal and rectal application, specifically.
- Development of mechanistic physiologically-based in vitro-in vivo correlations (IVIVCs) for dermally applied with discussion around case studies
- Virtual bioequivalence for dermally applied with discussion around case studies
Certificate
By completing/passing this course, you will attain the certificate Non-oral Absorption
1.
Pre Course Questionnaire - Your experience, expectations and area of interest, an optional survey to take prior to the course.
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2.
Agenda
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3.
Simcyp Simulator Download instructions (Amazon Workspaces download)
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4.
Pre Recorded Introductions to the Simcyp Simulator and other useful information
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5.
Slide Decks and Files for Loading
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6.
Hands on Assignments
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7.
Presentation and Office Hour Recordings
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8.
Survey, please complete for Certificate of completion
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