Description
July 15-19, 2024 | ONLINE
This workshop will explain the principle of therapeutic protein pharmacokinetic and pharmacodynamic modelling. Distribution, clearance, FcRn recycling, target-mediated drug disposition (TMDD), and subcutaneous absorption will be covered for monoclonal antibodies and other therapeutic proteins. Additionally, the suppression of CYP enzymes by cytokines and thus interactions between biologics and small molecule drugs will be simulated. Participants will learn how to apply these models using case studies.
Live Online Courses
There are no refunds for Live Online courses. Certara retains the right to cancel the course 30 calendar days before the first session, in which case participants will receive a full refund.
Objectives
Key aspects covered in this course:
• The use of minimal physiologically-based pharmacokinetic models for both mAbs and other therapeutic proteins
• The use of the full PBPK models for therapeutic proteins available within the Simulator
• Prediction of pharmacokinetics of therapeutic proteins in populations as well as in an average individual
• Utilisation of the 2-pore calculation to predict the distribution of therapeutic proteins
• Use of the allometric calculator tool
• The effect of FcRn affinity and charge state on the pharmacokinetics of monoclonal antibodies
• Demonstrating the utility of the target mediated drug disposition models (TMDD) within the Simulator
• The use of TMDD models that can account for the shedding of target from the cell surface into the interstitial space and plasma
• Linking the biologics/TMDD models to simulate pharmacodynamic effects
• Modelling the interaction between biologics and small molecule drugs
• Modelling subcutaneous / intramuscular absorption of therapeutic proteins
Certificate
By completing/passing this course, you will attain the certificate Certificate of Completion - Biologics
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